5,8,11,14-Tetraoxa-2-azahexadecanedioic acid
- Product Name
- 5,8,11,14-Tetraoxa-2-azahexadecanedioic acid
- CAS No.
- 437655-95-3
- Chemical Name
- 5,8,11,14-Tetraoxa-2-azahexadecanedioic acid
- Synonyms
- Fmoc-PEG4- CH2COOH;Fmoc-NH-PEG5-CH2CO2H;FMoc-NH-PEG4-CH2COOH;Fmoc-NH-PEG4-CH2CO2H;Fmoc-PEG4-acetic acid;Fmoc-N-Amido-PEG4-CH2COOH;5,8,11,14-Tetraoxa-2-azahexadecanedioic acid;1-Hydroxy-1-oxo-5,8,11,14-tetraoxa-2-azahexadecan-16-oic acid;1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16-pentaoxa-4-azaoctadecan-18-oic acid;14-[(9-Fluorenylmethoxycarbonyl)amino]-3,6,9,12-tetraoxatetradecanoic acid
- CBNumber
- CB62546849
- Molecular Formula
- C25H31NO8
- Formula Weight
- 473.52
- MOL File
- 437655-95-3.mol
5,8,11,14-Tetraoxa-2-azahexadecanedioic acid Property
- Melting point:
- 51℃
- Boiling point:
- 681.3±55.0 °C(Predicted)
- Density
- 1.235±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- Oil
- pka
- 3.39±0.10(Predicted)
Safety
- HS Code
- 2942000090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0105401
- Product name
- Fmoc-NH-PEG4-CH2COOH
- Packaging
- 250mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- AS110733
- Product name
- 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16-pentaoxa-4-azaoctadecan-18-oic acid
- Purity
- 97%
- Packaging
- 250mg
- Price
- $174
- Updated
- 2021/12/16
- Product number
- CS-0105401
- Product name
- Fmoc-NH-PEG4-CH2COOH
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- CS-0105401
- Product name
- Fmoc-NH-PEG4-CH2COOH
- Packaging
- 1g
- Price
- $255
- Updated
- 2021/12/16
- Product number
- 280117
- Product name
- Fmoc-NH-PEG4-CH2COOH
- Purity
- >=95%
- Packaging
- 1g
- Price
- $287
- Updated
- 2021/12/16
5,8,11,14-Tetraoxa-2-azahexadecanedioic acid Chemical Properties,Usage,Production
Description
Fmoc-NH-PEG4-CH2COOH is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Biological Activity
Fmoc-NH-PEG4-CH2COOH is a degradable ADC linker for antibody drug conjugate (ADC) synthesis. It is also a PEG-based PROTAC linker, which can be used for PROTAC synthesis.
in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
target
| Cleavable
| Alkyl/ether
| PEGs
|
5,8,11,14-Tetraoxa-2-azahexadecanedioic acid Preparation Products And Raw materials
Raw materials
Preparation Products
5,8,11,14-Tetraoxa-2-azahexadecanedioic acid Suppliers
View Lastest Price from 5,8,11,14-Tetraoxa-2-azahexadecanedioic acid manufacturers
- Product
- 5,8,11,14-Tetraoxa-2-azahexadecanedioic acid 437655-95-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-03